Intermittent fasting appears to cause changes in both the brain and the gut. It affects areas of the brain linked to hunger and self-control, and also shifts the balance of gut bacteria. These changes seem to work together over time, helping with weight loss and possibly improving how we manage food cravings.
The study shows that a two‑month intermittent energy restriction (IER) program induced dynamic, coupled changes in the gut microbiome and brain activity among 25 obese Chinese adults. Participants lost an average of 7.6kg (~7.8% body weight) under a three‑phase diet alternating regular intake with highly and then less controlled fasting.
Functional MRI revealed progressive reductions in activity in brain regions linked to appetite and addiction – such as the inferior frontal orbital gyrus, putamen, anterior cingulate cortex, and dorsolateral prefrontal cortex.
Simultaneously, gut microbiome diversity increased during the strict fasting phase, alongside increases in beneficial species (Faecalibacterium prausnitzii, Parabacteroides distasonis, Bacterokles uniformis) and a decrease in pathogenic E.coli.
Notably, the abundance of Coprococcus comes and Eubacterium hallii correlated negatively with frontal brain activity during the diet.
These findings suggest a temporally coordinated shift in the brain–gut–microbiome (BGM) axis during weight loss, though the causal mechanisms remain unclear.


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