the molecular and lifestyle interventions to slow cognitive decline and diseases like Alzheimer’s. Key points include the importance of longevity pathways (Sirtuins, AMPK, mTOR), the benefits of a Mediterranean diet, omega-3 fatty acids, and aerobic exercise. Supplements like NAD boosters and metformin are highlighted for their roles in improving blood flow, reducing amyloid beta, and enhancing cognitive function. Sleep, particularly maintaining circadian rhythms, is also critical to brain health.
- Diet: Adopting a Mediterranean diet, rich in olive oil, red wine, and plant-based foods, can protect brain health. This diet mimics adversity, activating longevity pathways like Sirtuins, which help slow cognitive aging.
- Exercise: Regular aerobic and strength training improves blood flow, supports cognitive function, and boosts neurogenesis (growth of new brain cells), reducing risks of dementia and age-related decline.
- Supplements: Supplements like omega-3 fatty acids, resveratrol, and NAD boosters (e.g., NMN, metformin) enhance brain health by increasing blood flow, reducing inflammation, and activating protective mechanisms.
- Sleep: Maintaining good sleep hygiene, including exposure to natural light in the morning and supplementing with magnesium or NMN, is vital for brain recovery and slowing cognitive aging.
- Brain stimulation: Keep the brain active and adaptable through lifelong learning and engagement with modern technology, which promotes mental plasticity and cognitive resilience.
These interventions aim to slow or reverse brain aging by supporting cellular health, reducing cognitive decline, and preventing diseases like Alzheimer’s.
David A. Sinclair, A.O., Ph.D. is a tenured Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, known for his research and controversial claims on aging and epigenetics.
https://sinclair.hms.harvard.edu/people/david-sinclair
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