The podcast “Lifespan” by Dr. David Sinclair, a Harvard Medical School professor, explores the science of aging and how to live a longer, healthier life. Topics include breakthroughs in anti-aging research, dietary practices, lifestyle changes, and the roles of specific genes in aging. Emphasizing that aging is a controllable process, Sinclair discusses methods for potentially reversing aging and extending lifespan through a combination of lifestyle adjustments and cutting-edge science.
- Aging is a controllable process that can be slowed and reversed.
- Minor adversities, like fasting or exercise, activate longevity genes (AMPK, mTOR, and sirtuins).
- Proper diet and timing (e.g., intermittent fasting) enhance lifespan and improve health.
- Supplements and medications like metformin or rapamycin can help extend lifespan.
- Biological age, measured via DNA methylation, is more important than chronological age.
- A fundamental cause of aging is the unspooling of DNA, leading to cellular confusion and age-related diseases.
David A. Sinclair, A.O., Ph.D. is a tenured Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, known for his research and controversial claims on aging and epigenetics.
https://sinclair.hms.harvard.edu/people/david-sinclair
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