The importance of exercise and adversity mimetics in activating longevity pathways. David Sinclair explains how vigorous exercise, intermittent fasting, and exposure to temperature extremes (cold and heat) mimic biological adversity, turning on protective genes like mTOR, AMPK, and sirtuins. These approaches boost metabolic function, slow aging, and combat diseases like cancer. Cold therapy promotes brown fat, while heat triggers beneficial proteins. Emerging treatments like hyperbaric oxygen therapy also show potential to enhance health.
David A. Sinclair, A.O., Ph.D. is a tenured Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, known for his research and controversial claims on aging and epigenetics.
https://sinclair.hms.harvard.edu/people/david-sinclair
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