Researchers report that phytoene, a natural carotenoid pigment found in many fruits and vegetables, helped laboratory worms live longer and show fewer signs linked to Alzheimer’s disease. In tests with the model animal Caenorhabditis elegans, phytoene lengthened lifespan and delayed paralysis related to toxic protein buildup.
The team tested both pure phytoene and microalgae extracts rich in this compound. The extracts had similar protective effects, which suggests phytoene itself is an active part of the benefit. Carotenoids are plant pigments that can act as antioxidants, they help limit damage from reactive molecules inside cells.
This is early evidence in a simple animal model, not in people. Results in worms often guide human studies, but they do not prove that eating more phytoene will slow aging or protect the human brain. The authors and news releases describe the work as promising and call for studies to discover how the effect works and whether it applies to higher animals.
Key terms:
- Caenorhabditis elegans is a small nematode often used to study aging and disease, because its biology is well mapped and its lifespan is short.
- Amyloid plaques are clumps of a protein fragment, amyloid beta, that build up between nerve cells in Alzheimer’s disease and can harm cells.
Antioxidants – Phytoene and Phytoene-Rich Microalgae Extracts Extend Lifespan in C. elegans and Protect against Amyloid-β Toxicity in an Alzheimer’s Disease Model – 2024
Peer reviewed research shows that phytoene, given either as a pure compound or via phytoene-rich microalgae extracts, increases lifespan and reduces amyloid-related toxicity in the C. elegans model. The authors suggest antioxidant action and proteostasis support as possible explanations and call for further mechanistic work and tests beyond worms.
PubMed – Phytoene and Phytoene-Rich Microalgae Extracts Extend Lifespan in C. elegans and Protect against Amyloid-β Toxicity in an Alzheimer’s Disease Model – 2024
Bibliographic record confirming the article, authors, journal issue, and DOI, with the abstract describing lifespan extension and protection against amyloid beta toxicity in the worm model.
University of Seville via EurekAlert – A dietary compound that increases longevity and protects against Alzheimer’s disease in experimental models – 2024
Institutional news release announcing the findings, highlighting that phytoene lengthened lifespan and reduced signs linked to amyloid toxicity in C. elegans, and noting plans to study mechanisms and broader applications.
0 Comments