Recent advancements in nanotechnology have led to the creation of tiny robots, or nanobots, that can be injected into the human bloodstream to perform highly precise medical tasks. Developed by scientists at the University of Edinburgh, these nanobots are coated with blood-clotting drugs and are designed to melt at specific temperatures to release medication exactly where needed. This breakthrough has significant potential for treating brain aneurysms by reducing the need for invasive surgeries and implants like stents or coils. Using magnets, researchers successfully guided these nanobots to the site of an aneurysm, where they clustered, heated up, and released their therapeutic payload, preventing dangerous brain bleeds. This technique minimizes the risk of drug leakage and could revolutionize treatment for other vascular conditions like strokes.
The study on nanobots capable of treating brain aneurysms was published in Small journal in 2024. It demonstrates the potential of these tiny, magnetically controlled robots to precisely deliver blood-clotting drugs directly to aneurysms, reducing the risk of dangerous brain bleeds. The nanobots, which are about a 20th the size of a red blood cell, can be injected into the bloodstream and guided to the site of an aneurysm using external magnets and medical imaging. Once they reach the target area, they cluster together, heat up, and release the therapeutic drugs at the exact location, minimizing the risk of drug leakage.
This innovative method offers a less invasive alternative to traditional treatments, which often involve threading catheters through complex blood vessels to place metal coils or stents. The technique could significantly reduce surgery time, lower the risk of complications, and potentially provide a solution for larger aneurysms that are more difficult to treat with existing methods.
https://www.eng.ed.ac.uk/about/news/20240909/tiny-magnetic-robots-could-treat-bleeds-brain
Innovative magnetic nanorobots offer new non-invasive therapy for intracranial aneurysms
A novel approach for treating intracranial aneurysms has been developed, utilizing thermally responsive magnetic nanorobots. These nanorobots, coated with a phase-change material and thrombin, are guided to aneurysms using a magnetic field system. Upon reaching the target, they release thrombin to induce aneurysm occlusion, activated by magnetic hyperthermia. This method avoids the complications of traditional stent-assisted coiling, such as stenosis and reliance on antiplatelet agents. The treatment is monitored with real-time ultrasound and confirmed through post-procedure angiography and histological analysis, offering a promising alternative for aneurysm therapy with improved safety and effectiveness.
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