A large research review has modeled how weekly training sets relate to muscle size and strength. The authors combined many resistance training studies and treated weekly sets as a continuous dose. They also counted exercises in two ways. A direct set targets the muscle that is measured, and an indirect set is a supporting exercise. Indirect sets were counted as half a set, a method the authors call fractional counting. This helps compare very different programs on the same scale. The models show that more weekly sets generally give more muscle and more strength, but the extra benefit gets smaller as volume rises. For muscle size, the slope stays positive even at higher volumes. For strength, the benefit flattens much sooner. Frequency, meaning how many sessions per week, adds little for muscle size when total weekly sets are the same, but it helps strength modestly, with smaller gains as frequency rises. The work is a preprint, so it has not yet been peer reviewed.
Practical ranges reported by coverage of this preprint suggest that about four weekly sets per muscle can produce detectable growth. A simple target of five to ten weekly sets per muscle looks effective for size. For strength, very low volumes can work. Around one set per week can yield small, detectable strength gains, and about two weekly sets per muscle is a practical target, with gains flattening near four sets. These figures should be read as guidance, not hard limits, and they fit the model that shows faster early returns and slower returns at higher volumes.
For people with limited time, these findings support a simple rule. Focus on a small number of quality sets that get close to muscular failure, and spread them across the week in a way that you can recover from. Programs can count both direct and indirect work, using indirect sets at half weight in your tally. Individual response, exercise choice, training age, recovery, and sleep still matter, and results will vary.
SportRχiv preprint – The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain – 2024
Preprint that models weekly set volume and frequency against muscle size and strength. Introduces fractional counting that scores indirect sets as half sets. Finds a positive dose response for both size and strength, smaller added benefits at higher volumes, minimal added effect of frequency on size when weekly sets are equal, and a modest positive effect of frequency on strength with diminishing returns. Not yet peer reviewed.
BarBend – Latest Meta-Analysis on Training Frequency for Hypertrophy – 2025
Explains the SportRχiv preprint in practical terms. Reports a minimum of roughly four weekly sets per muscle for growth, with five to ten sets as an effective range. Notes that gains continue at higher volumes but with slower returns.
Journal of Sports Sciences – Dose response between weekly resistance training volume and muscle mass – 2017
Earlier peer reviewed meta-analysis that supports a graded dose–response between weekly set volume and hypertrophy. Provides context for the new modeling by showing that more weekly sets generally lead to more growth, within the ranges studied.
U.S. News, summary of per session analysis inspired by the same group – Building Strength May Take Less Exercise Than You Think – 2025
Plain language coverage of a related per session meta-regression that also uses fractional counting. Reports faster early returns and a small sweet spot for strength per session, which aligns with the idea of strong diminishing returns at low volumes for strength.
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