Vigorous exercise may lead to a temporary rise in the levels of certain proteins linked to cell damage, which could increase the risk of clotting. These proteins, called circulating extracellular vesicles (EVs), are produced during intense physical activity and can promote clot formation under certain conditions. While regular exercise is still beneficial for overall health, the discovery raises questions about the short-term cardiovascular impacts of high-intensity workouts.
Scientists studying firefighters during intense training found that vigorous exercise significantly alters molecular activity, including reducing inflammation and changing the oral microbiome. While reduced inflammation improves breathing, it may also increase susceptibility to viral respiratory infections in the days following exercise. The research aims to enhance safety for first responders and others who engage in extreme physical activity by identifying early signs of exhaustion and vulnerability to infections.
Scientists used multi-omics analysis to study the effects of intense physical activity in firefighters, revealing that such exercise induces tissue damage and repair responses, shifts in lipid and carbohydrate metabolism, and changes in immune regulation. These findings highlight the complex physiological and biochemical adaptations that help maintain energy levels and fluid balance while potentially increasing vulnerability to respiratory infections after strenuous exertion. The study aims to improve health monitoring for workers in high-demand professions.
https://mmrjournal.biomedcentral.com/articles/10.1186/s40779-023-00477-5
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