When it comes to exercise for managing or preventing type 2 diabetes, cardio activities like running have long been the standard recommendation. However, a new study in mice suggests that strength training for diabetes prevention may have an edge, offering superior benefits for controlling blood sugar and reducing the specific types of fat linked to metabolic disease.
The research, led by scientists at Virginia Tech’s Fralin Biomedical Research Institute, directly compared the effects of endurance exercise (running) with resistance exercise (weightlifting). While both types of activity improved health, the weightlifting group showed significantly better results in improving glucose tolerance and insulin sensitivity, key factors in the fight against diabetes.
How strength training helps insulin resistance
To understand how different workouts affect the body, researchers used a common model for studying obesity and type 2 diabetes: mice fed a high-fat diet. These mice develop insulin resistance, meaning their bodies struggle to use blood sugar for energy, similar to humans at risk for diabetes.
The team divided the obese mice into three groups: one remained sedentary, one had 24/7 access to a running wheel for endurance exercise, and one performed resistance training.
After eight weeks, both exercise groups were healthier than the sedentary group. They had less fat and better blood sugar control. But the weightlifting mice outperformed the runners in nearly every key metabolic measure. They lost more visceral fat (the harmful fat around internal organs) and showed more significant improvements in glucose tolerance and insulin signaling in their muscles.
A new way to study weightlifting in mice
A major challenge in this type of research has been finding a way to get mice to “lift weights.” The researchers, led by Professor Zhen Yan, developed an innovative model to solve this.
The mice lived in special cages where they had to lift a small, weighted lid to access their food. This squat-like movement mimics the muscle contractions of human resistance exercise. The load was gradually increased over the study, forcing the mice to build strength, just as a person would in the gym.
Why strength training metabolism is different
Perhaps the most important finding was why strength training worked so well. The superior benefits were not simply because the mice built more muscle mass.
Instead, the researchers suggest that resistance exercise activates unique metabolic pathways that endurance training does not. This type of training targets fast-twitch muscle fibers, which are not used as much during light running.
According to external experts commenting on the study, training these fibers increases the muscle’s “storage space” for blood sugar, pulling more of it out of the bloodstream. It also appears to flip molecular switches, like the mTOR and calcium pathways, that improve the body’s sensitivity to insulin, independent of fat loss.
Strength training vs running: which is best?
This study provides strong preclinical evidence that strength training is a powerful tool against metabolic disease. For people who cannot engage in endurance exercise, Dr. Yan noted that “weight training has equal, if not better, anti-diabetes benefits.”
However, this is an animal study, and the findings need to be confirmed in human trials. Experts also caution against giving up on cardio, which has proven benefits for heart and lung health and often burns calories at a faster rate.
Previous research has already shown that strength training outperforms cardio for fat loss and metabolic health in humans, and that lifting weights is the best way to slow muscle loss as we age.
Ultimately, the study’s lead author and other experts agree on the main takeaway: the best plan is to do both. “The take-home message is that you should do both endurance and resistance exercise, if possible, to get the most health benefit,” Yan concluded.
What you can do about it
This research adds to a growing body of evidence supporting the importance of strength training for overall health, not just for building muscle.
- If you are at risk for type 2 diabetes, incorporating resistance exercise into your routine may provide unique benefits for improving insulin sensitivity and reducing harmful fat.
- This does not mean you should stop doing cardio. A balanced routine that includes both strength and endurance work is considered the best approach for most people.
- As with any new exercise program, discuss the best options for your specific health needs with your doctor or a healthcare professional.
Sources & related information
Journal of Sport and Health Science – Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice – 2025
This is the original animal study that compared resistance training to endurance running in mice fed a high-fat diet. It found that while both exercise types helped, the weightlifting group showed superior improvements in fat loss, glucose tolerance, and insulin sensitivity.
Virginia Tech News – Weightlifting beats running for blood sugar control, researchers find – 2025
The official press release from the researchers’ institution, Fralin Biomedical Research Institute at Virginia Tech. It details the study’s findings and quotes the lead author, Zhen Yan, on the importance of the results and the recommendation to do both types of exercise.
Newsweek – Running or Weightlifting? Study Reveals Which Is Better for Diabetes – 2025
This news report summarizes the Virginia Tech study and includes commentary from external experts. It provides context on how strength training may work differently by training fast-twitch muscle fibers and activating specific molecular pathways.
The Independent – This is the exercise you need to combat obesity and diabetes, new study says – 2025
This article covers the same study and includes balancing commentary from other professors. One expert emphasizes that running is still excellent for heart health and burns calories faster, while another notes that people should do the type of exercise that suits them most.
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