Most movement is good for health. But a recent human study suggests that bouts of very vigorous exercise can, for a short time, make the immune system less effective. This matters for people who push hard at work or sport, like firefighters or endurance athletes. In this article we explain what the research found, what “leaky gut” during hard exercise means, and how to train smart while keeping the many benefits of exercise.
Vigorous exercise and the immune system: what the new study found
Evidence type and key result
A peer‑reviewed human experiment tracked 11 young wildland firefighters who did a 45‑minute, intense outdoor workout while wearing full gear. Researchers sampled blood, saliva, and urine before and after and measured thousands of molecules using “multi‑omics,” a lab approach that maps proteins, lipids, and metabolites. After the workout, the firefighters showed signs of tissue stress and repair, and a pattern in saliva of fewer pro‑inflammatory cytokines but more antimicrobial peptides, alongside a literature review that links hard efforts with a higher short‑term risk of respiratory infections. The authors conclude that very intense work may create a brief window of lowered immune defense and advise extra caution around respiratory bugs for people in highly physical jobs (Military Medical Research, 2023).
How could hard exercise lower defenses for a while?
When we push near our limits, body heat, stress hormones, and blood flow shifts help power the effort, but they can also divert resources away from the gut and immune system. Reviews in exercise immunology describe a short “open window” after long or very hard sessions when some white‑blood‑cell functions dip, which may let viruses or bacteria get a foothold (2018 review in Exercise Immunology).
Leaky gut during hard efforts: what it is and why it matters
Leaky gut definition
“Leaky gut” in this context means the intestinal barrier becomes more permeable. Tight junctions between gut cells loosen under heat, low blood flow, and mechanical stress. This can let small amounts of bacterial components (like endotoxin) enter the blood and trigger an immune response.
Evidence in athletes and hot conditions
A synthesis of studies reports that vigorous endurance work for ≥60 minutes at ≥70% capacity—especially in heat, at altitude, or when dehydrated—can raise gut permeability and mild endotoxemia signs (2021 overview; 2022 review). New 2025 work also indicates that heat stress during exercise can affect both paracellular and transcellular gut pathways (2025 study).
What this means for sickness risk
The firefighter paper also reviewed past field studies and found more respiratory symptoms in the days after marathons and military‑style training than in matched controls. That does not prove cause and effect, but it supports the idea of short‑term vulnerability after very hard efforts (Military Medical Research, 2023).
How much is too much? Practical guardrails for training
Keep most sessions moderate
For general health and fat loss, most people do well with regular walking and strength work. Gentle daily movement is easier to repeat and lowers injury risk. See our overview on why walking is the simplest way to lose fat and why after 40, lifting weights slows muscle loss.
Taper intensity and plan recovery
According to those information (not medical advice – you need to double check), if you love hard workouts:
- Limit very hard sessions to 2–3 times per week, spaced out.
- Add cooling, fluids, and shade in hot weather; plan the hardest efforts in cooler hours.
- Refuel with carbs and fluids soon after long or hot sessions.
- Sleep 7–9 hours; schedule an easier day after races or heat exposure.
- Avoid crowded indoor spaces right after an extreme effort, when you may be in that short “open window.”
Watch for warning signs
Take a lighter day if you notice: unusual fatigue, gut cramps during training, reduced appetite, rising morning heart rate, or frequent colds.
Limitations and quality of evidence
- The firefighter study is small (n = 11, male) and measures biomarkers, not infections directly. It suggests mechanisms and risk, not proof of disease.
- Exercise overall reduces long‑term illness risk; most data showing a brief dip in defenses follow very hard or long efforts, often with heat or dehydration.
- Some experts argue the infection risk after exercise is lower than once thought, so context matters (2018 review).
Bottom line
Keep moving, exercise is one of the best tools for health. If you push very hard, especially in heat, plan recovery and hygiene for the next 3–24 hours. That helps keep the gains while lowering any short‑term immune dip.
Military Medical Research – Elucidating regulatory processes of intense physical activity by multi‑omics analysis – 2023
A human multi‑omics study in wildland firefighters found biomarker patterns after a 45‑minute intense workout that suggest a brief dip in immune defense and reviewed past studies linking hard efforts to more respiratory symptoms (the peer‑reviewed paper). Evidence type: human experiment; funding: US agencies including PNNL and CDC NIOSH (see paper disclosures).
Exercise Immunology Review – Debunking the myth of exercise‑induced immune suppression: redefining the impact of exercise on immunological health – 2018
This influential review argues that routine exercise supports immunity and that infection risk after exercise is often overstated, while acknowledging transient post‑exercise changes in some immune measures (review article). Evidence type: narrative review.
Frontiers in Physiology – Gastrointestinal function and microbiota in endurance athletes – 2025
A minireview outlines how hard endurance work and environmental heat stress the gut barrier and discusses strategies to optimize GI function for athletes (minireview). Evidence type: narrative review.
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