Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in people over 50. A large U.S. electronic-health-record study, recently published in JAMA Ophthalmology, links daily curcumin-based nutritional supplements (the active compound in turmeric) with markedly lower odds of developing, or seeing the rapid progression of, both dry and wet forms of AMD.
Researchers compared tens of thousands of supplement users with more than 1 million non-users who were otherwise similar in age, sex and health profiles. Supplement users were far less likely to reach advanced stages of the disease, lose central vision or need sight-saving anti-VEGF eye injections.
Because the work is an observational, retrospective analysis, it shows association—not proof of cause and effect. The authors and outside experts caution that unknown factors such as diet, income or general “healthy-user” behaviour could partly explain the benefit, and the study did not track brand, dose or formulation of curcumin. Randomised clinical trials are needed before doctors can recommend the spice compound as standard care.
Even so, the findings strengthen earlier laboratory and small-scale human data suggesting curcumin’s anti-inflammatory and antioxidant properties may help shield retinal cells from damage. For now, ophthalmologists still stress proven lifestyle measures, no smoking, regular exercise, and an antioxidant-rich diet, but note that curcumin supplements appear safe for most people who want to try them after consulting their physician.
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