A clinical psychologist who studies supplements, Dr. Adrian Lopresti, says his own routine centers on three products chosen for mental well being and day to day performance. Insider also notes that he helps run a contract research company that conducts trials for supplement makers, and that any products he is currently studying in sponsored trials were excluded from his picks.
Fish oil for brain and heart support
Fish oil supplies omega 3 fatty acids, which are nutrients found in fish. Research reviews suggest moderate daily intake helps lower blood pressure and may ease symptoms of depression when used alongside standard care. These effects are thought to relate to anti inflammatory actions in the body.
Magnesium for muscles and recovery
Magnesium is a mineral needed for muscle and nerve function. Evidence for performance benefits is mixed, with possible advantages mainly when intake is low, and some forms are better tolerated than others. Products labeled glycinate or citrate are commonly chosen because oxide can act as a laxative.
Ashwagandha for stress management
Ashwagandha, an adaptogen, is a plant extract used to help the body handle stress. Trials and meta analyses show reductions in perceived stress and anxiety for many people. Effects build with steady use over several weeks, not overnight.
Bottom line
These three supplements have evidence that is promising but not definitive. Benefits are most likely when paired with healthy sleep, diet, and exercise, and when choices are made with a clinician who can check for interactions or health risks.
Journal of the American Heart Association – Omega 3 polyunsaturated fatty acids intake and blood pressure, a dose response meta analysis – 2022
Across randomized trials, a moderate daily amount of EPA plus DHA was linked with small reductions in blood pressure, supporting fish intake or fish oil for cardiovascular risk factors.
Translational Psychiatry – Meta analysis and meta regression of omega 3 for major depressive disorder – 2016
Pooled clinical trials show omega 3 supplements produce a small but significant reduction in depression symptoms, with stronger effects for EPA rich formulations and as add on to antidepressants.
Medicine (Baltimore) – An investigation into the stress relieving and pharmacological actions of ashwagandha in adults under chronic stress, a randomized controlled trial – 2019
Eight week trial found ashwagandha reduced anxiety and morning cortisol versus placebo, suggesting stress relieving effects, while calling for larger and longer studies.
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