A new study has identified that the frontostriatal salience network, a brain region tied to reward processing and external stimuli filtering, is nearly twice its usual size in people with depression. Researchers from Weill Cornell Medicine found that this network expands by shifting into areas typically controlled by other networks. The expansion was detected in both adults and children, suggesting it may be a genetic risk factor for depression, appearing even before diagnosis. While promising, more research is needed to confirm the network’s role in depression.
Frontostriatal network expansion identified as a stable risk factor for depression
A study published in Nature reveals that the frontostriatal salience network is nearly twice its normal size in individuals with depression, marking it as a potential risk factor rather than a result of the disorder. Researchers found that this network expansion remains stable over time, unaffected by mood changes, and is detectable in children before depression onset. The study suggests that this network alteration is a genetic trait-like feature linked to depression, with distinct shifts into neighboring brain regions. Further analysis revealed changes in functional connectivity within the salience network predict the severity and fluctuation of depressive symptoms such as anhedonia.
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