Neuroscientists at Wellesley College have found experimental evidence that challenges the standard view of how the brain produces the mind. By showing that a drug which stabilizes microscopic protein structures called microtubules keeps rats awake longer under anesthesia, the team supports a controversial theory: that consciousness is not just a product of electrical signals between neurons, but a quantum phenomenon happening inside them.
This finding gives new weight to the “Orch OR” theory proposed by Nobel laureate Roger Penrose and anesthesiologist Stuart Hameroff, which suggests our minds might have a physical basis that connects us more deeply to the universe.
The experiment: stabilizing brain structures delays anesthesia
For decades, scientists have debated how anesthetic gases work. The standard view is that they bind to proteins on the surface of neurons to block electrical signals. A different view suggests they act on microtubules, the tiny, tube-like protein structures that give cells their shape and act as tracks for moving cargo inside the cell.
Professor Mike Wiest and his team of undergraduate students at Wellesley College tested this second idea. They injected rats with a drug called epothilone B, which enters the brain and binds specifically to microtubules, making them stiff and stable. They then exposed the rats to a common anesthetic gas, isoflurane, and measured how long it took for the animals to lose consciousness.
The results were clear. Rats that received the microtubule-stabilizing drug stayed awake significantly longer – 69 seconds longer on average – than rats that received a placebo. Because the drug locks microtubules in place, it seemingly made it harder for the anesthetic gas to disrupt them and shut down consciousness.
Why this supports the quantum theory of consciousness
If stabilizing microtubules fights off the effects of anesthesia, it suggests that anesthesia works by disrupting microtubules. And if disrupting microtubules turns off consciousness, then microtubules must be essential for generating consciousness in the first place.
The classical view vs. the quantum view
The mainstream “classical” model of neuroscience treats the brain like a complex computer network. In this view, consciousness emerges from the pattern of electrical spikes firing across billions of neurons and the chemical signals passing between them at synapses.
The quantum model goes deeper. It argues that the real action happens inside the neurons, within the hollow cores of microtubules. Proponents believe these structures act as quantum computers, capable of processing information using the strange rules of quantum mechanics, such as superposition (being in two states at once).
Orch OR theory: microtubules as quantum computers
This aligns with the Orchestrated Objective Reduction (Orch OR) theory. It posits that consciousness arises from “quantum vibrations” in microtubule proteins. According to this theory, anesthetics cause unconsciousness by dampening these delicate quantum vibrations. The Wellesley study provides physical evidence for this: when the drug stabilized the microtubules, it likely protected those vibrations, keeping the rats conscious for longer.
Mike Wiest, the study’s lead author, explains the weight of this shift: “When it becomes accepted that the mind is a quantum phenomenon, we will have entered a new era in our understanding of what we are.”
What this means for our connection to the universe
Moving from a classical to a quantum view of the mind changes more than just textbooks; it changes how we see our place in nature. Classical physics sees the world as a machine of separate parts pushing against each other. Quantum physics reveals a world of deep connections, where particles can be linked across vast distances.
If our consciousness relies on quantum processes, it might be fundamentally connected to the rest of the universe in ways we do not yet understand. Wiest suggests this theory gives us a “world picture in which we can be connected to the universe in a more natural and holistic way.”
This research could also lead to better anesthesia, new treatments for coma or brain disorders, and a clearer understanding of which animals possess consciousness.
Sources & related information
Wellesley College – New research on anesthesia unlocks important clues about the nature of consciousness – 2024
A team led by Professor Mike Wiest found that stabilizing microtubules with a drug delayed the onset of anesthesia in rats, supporting the idea that consciousness depends on quantum processes within these cellular structures.
eNeuro – Microtubule-Stabilizer Epothilone B Delays Anesthetic-Induced Unconsciousness in Rats – 2024
The peer-reviewed study details how the drug epothilone B binds to tubulin protein, counteracting the effects of isoflurane gas and providing experimental support for microtubule-based theories of consciousness.
Popular Mechanics – Scientists Believe They’ve Unlocked Consciousness – 2024
This article reports on the Wellesley study, discussing how the findings bridge neuroscience and quantum physics and referencing the broader implications for understanding human existence.
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