Researchers have produced the first complete wiring diagram of an adult animal brain, a female fruit fly brain, showing how every neuron connects to every other through synapses. This full brain map, called a connectome, provides a concrete blueprint of neural circuitry that supports sight, movement and other behaviors.
The team imaged the whole brain at nanometer scale, then used artificial intelligence to trace neurons and synapses, followed by extensive human proofreading to ensure accuracy. The result covers roughly 140,000 neurons and more than 50 million synaptic connections, creating the largest and most detailed connectome available today.
Beyond the raw map, the consortium organized the brain into thousands of verified cell types, and predicted the likely neurotransmitter identity for neurons. This rich annotation helps scientists move from anatomy to function, for example by identifying which pathways are likely excitatory or inhibitory, and by grouping cells that share structure and connectivity.
The connectome suggests broad commonality in brain wiring. When compared with earlier partial maps, many circuits match closely, which supports the idea that individuals share core wiring patterns rather than each brain being unique. The dataset is openly accessible so researchers can analyze circuits for vision, navigation and action, and begin building realistic whole-brain simulations.
Although far simpler than the human brain, the fly is a powerful model for discovering general rules of brain organization. Techniques proven here, high-throughput electron microscopy, AI reconstruction and standardized cell typing, are expected to accelerate connectome efforts in larger animals and eventually inform human brain research.
Nature – Neuronal wiring diagram of an adult brain – 2024
The flagship paper presents the complete synapse-level wiring diagram of an adult female Drosophila brain, with open data products and analyses of information flow across sensory, central and motor systems.
Nature – Whole-brain annotation and multi-connectome cell typing of Drosophila – 2024
Companion study that defines a hierarchy of neuron classes and over 8,000 validated cell types across the whole brain, enabling consistent typing and cross-brain comparisons for modeling and analysis.
University of Cambridge – First map of every neuron in an adult fly brain complete – Oct 2, 2024
Press release explaining how the brain was cut into about 7,000 ultrathin slices, reconstructed with AI and human proofreading, and how the team predicted whether synapses are excitatory or inhibitory.
NIH Research Matters – Complete wiring map of an adult fruit fly brain – Oct 22, 2024
Overview of the connectome’s scale and significance, highlighting open access and its value as a platform for studying brain circuits across species.
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